G Quadruplex Nucleic Acids

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application.

G Quadruplex Nucleic Acids

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, G-Quadruplex DNA: Methods and Protocols is a valuable resource for both novice and experienced researchers who work in biophysics, structural biology, computational biology, biochemistry, and molecular and cell biology, and who want to learn more about the potential roles and effects of G-quadruplex in these fields.

More Books:

G-Quadruplex Nucleic Acids
Language: en
Pages: 437
Authors: Danzhou Yang, Clement Lin
Categories: Medical
Type: BOOK - Published: 2019-08-24 - Publisher: Humana

This volume covers the structures, properties, and functions of G-quadruplexes in a wide range of biological disciplines, including therapeutic intervention and biomaterial application. The chapters in this book explore a wide range of vital and new experimental techniques used in the study of G-quadruplexes. Written in the highly successful Methods
Quadruplex Nucleic Acids
Language: en
Pages: 301
Authors: Stephen Neidle, Shankar Balasubramanian
Categories: Science
Type: BOOK - Published: 2007-10-31 - Publisher: Royal Society of Chemistry

Guanine rich DNA has been known for decades to form unusual structures, although their biological relevance was little understood. Recent advances have demonstrated that quadruplex structures can play a role in gene expression and provide opportunities for a new class of anticancer therapeutics. A number of quadruplex-specific proteins have also
Quadruplex Nucleic Acids
Language: en
Pages: 278
Authors: Jonathan B. Chaires, David Graves
Categories: Science
Type: BOOK - Published: 2014-07-08 - Publisher: Springer

Gaining Insights into the Small Molecule Targeting of the G-Quadruplex in the c-MYC Promoter Using NMR and an Allele-Specific Transcriptional Assay, by Christine E. Kaiser, Vijay Gokhale, Danzhou Yang and Laurence H. Hurley.- Higher-Order Quadruplex Structures, by Luigi Petraccone.- Investigation of Quadruplex Structure Under Physiological Conditions Using In-Cell NMR, by
Quadruplex Nucleic Acids As Targets For Medicinal Chemistry
Language: en
Pages: 564
Authors: Jonathan B. Chaires, David Graves
Categories: Science
Type: BOOK - Published: 2020-08-26 - Publisher: Academic Press

The realisation that human, animal, viral and bacterial genomes all contain over-representation of higher-order quadruplex structures in regulatory and other pharmacologically-useful regions, has led to a large number of studies aimed at exploiting this findings for therapeutic and diagnostic purposes. Quadruplex-binding small molecules are starting to be evaluated in human
Therapeutic Applications of Quadruplex Nucleic Acids
Language: en
Pages: 196
Authors: Stephen Neidle
Categories: Science
Type: BOOK - Published: 2011 - Publisher: Academic Press

New found interest in the chromosome G-quadruplexes has emerged as an important focus of research in nucleic acids and as a potential target for cancer therapeutics. Existing literature concerning nucleic acids concentrates on aspects of quadruplex structure and historical research. There exists no single comprehensive resource addressing recent advances in